Ozonized Unsaturated Triglycerides as Precursors of Urinary Dicarboxylic Acids

نویسندگان

  • Daniel Jardines
  • Oscar Ledea
چکیده

Oral administration of ozonized sunflower oil to Wistar rats has produced changes in the urinary content of dicarboxylic acids. Heptanedioic acid (Pimelic acid) and nonanedioic acid (Azelaic acid) were the major increased dicarboxylic acids founded. The aim of this work is the study of the urinary dicarboxylic acid profiles of Wistar rats, orally treated with ozonized standard triglycerides. The dicarboxylic acids were extracted and derivatized before the analysis by Gas Chromatography Mass Spectrometry. The urinary dicarboxylic acid profiles of the rats that received ozonized triolein, only showed the increasing of heptanedioic and nonanedioic acids. However, when ozonized trilinolein was applied, the profile is similar to that obtained, when ozonized sunflower oil was administered. A biochemical mechanism to explain the formation of dicarboxylic acids from ozonated unsaturated triglycerides was proposed.

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تاریخ انتشار 2015